Acetylcysteine Impurity 46 Disodium Salt CAS 282727-77-9(Free Acid)
| CAS No. | 282727-77-9(Free Acid) |
| Molecular Formula | C5H7NO5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Acetylcysteine Impurity 46 Disodium Salt (CAS 282727-77-9(Free Acid)), a pharmacopoeial impurity reference standard (molecular formula C5H7NO5SNa, MW 216.16 g/mol) used for the identification and quantification of trace impurities in APIs.
Acetylcysteine Impurity 46 Disodium Salt (C5H7NO5SNa) contains a carbohydrate-derived structure, an amide group, a sulfone group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C5H7NO5S 2*Na |
| Molecular Weight | 216.16 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Acetylcysteine Standards
- Acetylcysteine Impurity 12 (CAS 1115-65-7)
- Acetylcysteine Impurity 41 (CAS 13100-82-8)
- N-Acetylcysteine-d3 (CAS 131685-11-5)
- Acetylcysteine Impurity 33 (CAS 15058-19-2)
- Acetylcysteine Impurity 37 (CAS 155172-79-5)
- Acetylcysteine Impurity 18 (CAS 1637-71-4)
- Acetylcysteine impurity 66 (CAS 16708-09-1)
- Acetylcysteine EP Impurity D (CAS 18725-37-6)
Recommended Standards
- Pitavastatin Impurity 103 (CAS CATO-C4X-1037103)
- Fludarabine Phosphate EP Impurity C Disodium Salt (CAS CATO-C4X-184621)
- CAS CATO-C3D-262677 (CAS CATO-C3D-262677)
- 2-Fluoropyridine 1-oxide (CAS 7613-14-1)
- Trans-2-tert-butoxycarbonylamino-cyclopent-3-enecarboxylicacidmethylester (CAS 1272666-21-3)
- 6-Methoxyimidazo[1,2-a]pyrazine-3-carboxylic acid (CAS 1554409-07-2)
- 2-(4-Methyl-4h-1,2,4-triazol-3-yl)aniline (CAS 1087792-28-6)
- 4-Methyl-2-(4-(trifluoromethoxy)phenyl)thiazole-5-carboxylic acid (CAS 187998-69-2)
- 2-Methylcinnamic Acid (CAS 2373-76-4)
- Polymyxin B nonapeptide (CAS 86408-36-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com